Respiratory Influenza viral load as a marker of poor prognosis in patients with severe symptoms
نویسندگان
چکیده
The link between influenza virus (IV) viral load (VL) in respiratory samples and disease severity is not clearly established. This study was designed to assess IV-VL from flu patients admitted intensive care unit (ICU). Patients ICU for IV infection, as documented by RT-PCR, with failure were included the during 5 flu-seasons (2014–2018). Routine management parameters recorded. Real-time amplification Ct-values cell GAPDH gene measured each sample collected at admission. Among 105 patients, 59 (56.1%) presented an acute distress syndrome (ARDS). overall mortality 21%. IV-load assessed virus-over-cell ratio (expressed log10) ranged 20 40 −5.2–3.7, respectively, did differ according type of IV-A or -B type. Cell richness higher ARDS compared non-ARDS (p = 0.0003) but no difference noted Ct-values. In ARDS-patients, 0.020) virus-per-cell 0.038) significantly who eventually died those survived. These 2 remain independently associated odd-ratio 1.21 2.19, respectively < 0.05). While does seem predict evolution flu-patients, normalized measurement could be useful identify risk mortality.
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ژورنال
عنوان ژورنال: Journal of Clinical Virology
سال: 2021
ISSN: ['1386-6532', '1873-5967']
DOI: https://doi.org/10.1016/j.jcv.2021.104761